AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bermudez, L. E.
Right arrow Articles by Young, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bermudez, L. E.
Right arrow Articles by Young, L. S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, September 2004, p. 3556-3558, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3556-3558.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease

Luiz E. Bermudez,1,2,3* Peter Kolonoski,1 Lianne E. Seitz,4 Mary Petrofsky,1 Robert Reynolds,4 Martin Wu,1,2 and Lowell S. Young1

Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California,1 Department of Biomedical Science, College of Veterinary Medicine,2 Department of Microbiology, College of Science, Oregon State University, Corvallis, Oregon,3 Southern Research Institute, Birmingham, Alabama4

Received 11 December 2003/ Returned for modification 7 March 2004/ Accepted 16 May 2004

Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone.

* Corresponding author. Mailing address: 105 Dryden Hall, College of Veterinary Medicine, Corvallis, OR 97331. Phone: (541) 737-6538. Fax: (541) 737-8035. E-mail: luiz.bermudez{at}oregonstate.edu.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3556-3558, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3556-3558.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2004 by the American Society for Microbiology. All rights reserved.