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Antimicrobial Agents and Chemotherapy, September 2004, p. 3559-3562, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3559-3562.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Emergence of Macrolide-Resistant Streptococcus pyogenes Strains in French Children

Edouard Bingen,1* Philippe Bidet,1 Liliana Mihaila-Amrouche,2 Catherine Doit,1 Samuel Forcet,1 Naïma Brahimi,1 Anne Bouvet,2 and Robert Cohen3

Laboratoire d'Etudes de Génétique Bactérienne dans les infections de l'enfant (EA3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré,1 Centre National de Référence des Streptocoques, Université Paris 5, Service de Microbiologie, Hôtel-Dieu, Paris,2 Service de Microbiologie, Centre Hospitalier de Créteil, Créteil, France3

Received 29 January 2004/ Returned for modification 3 April 2004/ Accepted 11 May 2004

We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Robert Debré, 48 Bd Sérurier, 75019 Paris, France. Phone: 33 (1) 40 03 23 40. Fax: 33 (1) 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3559-3562, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3559-3562.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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