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Antimicrobial Agents and Chemotherapy, September 2004, p. 3559-3562, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3559-3562.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Emergence of Macrolide-Resistant Streptococcus pyogenes Strains in French Children

Laboratoire d'Etudes de Génétique Bactérienne dans les infections de l'enfant (EA3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré,¹ Centre National de Référence des Streptocoques, Université Paris 5, Service de Microbiologie, Hôtel-Dieu, Paris,² Service de Microbiologie, Centre Hospitalier de Créteil, Créteil, France³

Received 29 January 2004/ Returned for modification 3 April 2004/ Accepted 11 May 2004

We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.

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