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Antimicrobial Agents and Chemotherapy, September 2004, p. 3567-3569, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3567-3569.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh

Laboratory Sciences Division, ICDDR, B: Centre for Health and Population Research,¹ Dhaka Medical College Hospital, Dhaka, Bangladesh²

Received 25 January 2004/ Returned for modification 5 April 2004/ Accepted 1 May 2004

Twelve clarithromycin-resistant (MIC, 1 µg/ml) Helicobacter pylori isolates were analyzed for point mutations in the 23S rRNA gene. Sequence analysis of all of the resistant isolates revealed a T-to-C transition mutation at position 2182. Transformation experiments confirmed that a single T-to-C transition mutation at position 2182 is associated with clarithromycin resistance.

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