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Antimicrobial Agents and Chemotherapy, September 2004, p. 3570-3572, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3570-3572.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Quinolone-Resistant Haemophilus influenzae in a Long-Term-Care Facility: Nucleotide Sequence Characterization of Alterations in the Genes Encoding DNA Gyrase and DNA Topoisomerase IV

Public Health Research Institute, Newark, New Jersey,¹ Infectious Disease Section, New York Hospital Queens, Flushing, and Department of Microbiology and Medicine, Weill Medical College, Cornell University, New York, New York²

Received 3 February 2004/ Returned for modification 14 April 2004/ Accepted 14 May 2004

Fluoroquinolone-resistant isolates of Haemophilus influenzae, obtained from a long-term care facility, were examined for nucleotide sequence differences in the quinolone-resistance-determining regions of gyrA, gyrB, parC, and parE. Similarities among the resistant isolates, plus multiple differences with susceptible isolates, suggest clonal dissemination involving two resistant subclones.

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