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Antimicrobial Agents and Chemotherapy, September 2004, p. 3594-3597, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3594-3597.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Fusidic Acid-Resistant Epidemic Strain of Staphylococcus aureus Carries the fusB Determinant, whereas fusA Mutations Are Prevalent in Other Resistant Isolates

Alexander J. O'Neill,1 Anders R. Larsen,2 Anne S. Henriksen,3 and Ian Chopra1*

Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds, United Kingdom,1 Department of Research & Development, Statens Serum Institut, Copenhagen,2 LEO Pharma, Ballerup, Denmark3

Received 9 December 2003/ Returned for modification 3 March 2004/ Accepted 30 April 2004

Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant. In contrast, resistance to fusidic acid in a collection of nonepidemic strains resulted primarily from mutations in fusA.

* Corresponding author. Mailing address: Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 113 343 5604. Fax: 44 113 343 5638. E-mail: i.chopra{at}leeds.ac.uk.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3594-3597, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3594-3597.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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