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Antimicrobial Agents and Chemotherapy, September 2004, p. 3602-3605, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3602-3605.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Activities of Dicationic Compounds against Trichomonas vaginalis

Andrea L. Crowell,1 Chad E. Stephens,2 Arvind Kumar,2 David W. Boykin,2 and W. Evan Secor1*

Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services,1 Department of Chemistry, Georgia State University, Atlanta, Georgia2

Received 9 March 2004/ Returned for modification 19 April 2004/ Accepted 23 May 2004

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 µM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

* Corresponding author. Mailing address: Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724. Phone: (770) 488-4115. Fax: (770) 488-4108. E-mail: was4{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3602-3605, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3602-3605.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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