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Antimicrobial Agents and Chemotherapy, September 2004, p. 3610-3612, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3610-3612.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Convenient Biological Assay for Polyethylene Glycol-Interferons in Patients with Hepatitis C

Anne Boulestin,1* Nassim Kamar,2 Florence Legrand-Abravanel,1 Karine Sandres-Saune,1 Laurent Alric,3 Jean-Pierre Vinel,4 Lionel Rostaing,2 and Jacques Izopet1

Laboratoire de Virologie EA 2046-IFR 30,1 Service de Médecine Interne,3 Service d'Hépato-Gastro-Entérologie, CHU PURPAN,4 Unité de Transplantation d'Organes, CHU RANGUEIL, Toulouse, France2

Received 9 January 2004/ Returned for modification 18 March 2004/ Accepted 11 May 2004

The vesicular stomatitis virus cytopathic effect reduction assay is suitable to quantify polyethylene glycol-alpha interferon 2a (PEG-IFN-{alpha}2a) and PEG-IFN-{alpha}2b. Human serum and ribavirin did not interfere with the assay. This bioassay was successfully used for assaying PEG-IFN-{alpha}2a and PEG-IFN-{alpha}2b in serum samples from patients undergoing combination therapy.

* Corresponding author. Mailing address: Laboratoire de Virologie EA 2046-IFR 30, CHU PURPAN, Place du Dr Baylac, TSA 40031, 31059 Toulouse Cedex 9, France. Phone: 33 5 61 77 24 63. Fax: 33 5 61 77 25 42. E-mail: aboulestin{at}yahoo.fr.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3610-3612, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3610-3612.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Francois, C., Bernard, I., Castelain, S., Charleston, B., Fray, M. D., Capiod, J.-C., Duverlie, G. (2005). Quantification of Different Human Alpha Interferon Subtypes and Pegylated Interferon Activities by Measuring MxA Promoter Activation. Antimicrob. Agents Chemother. 49: 3770-3775 [Abstract] [Full Text]  


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