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Antimicrobial Agents and Chemotherapy, September 2004, p. 3621-3624, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3621-3624.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux in Enterobacter aerogenes and Escherichia coli

Renaud Chollet,1 Jacqueline Chevalier,1 André Bryskier,2 and Jean-Marie Pagès1*

Enveloppe Bactérienne, Perméabilité et Antibiotiques, EA2197, IFR48, Faculté de Médecine, Université de la Méditerranée, Marseille,1 Aventis Pharma SA, Infectious Disease Group, Romainville, France2

Received 27 October 2003/ Returned for modification 4 February 2004/ Accepted 3 May 2004

The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine ß-naphthylamide, expel macrolides and telithromycin in E. aerogenes.

* Corresponding author. Mailing address: EA2197, Faculté de Médecine, 27 Bd. Jean Moulin 13385, Marseille Cedex 05, France. Phone: (33) 4 91 32 45 29. Fax: (33) 4 91 32 46 06. E-mail: Jean-Marie.Pages{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3621-3624, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3621-3624.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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