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Antimicrobial Agents and Chemotherapy, January 2005, p. 170-175, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.170-175.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Ecological Effects of Perorally Administered Pivmecillinam on the Normal Vaginal Microflora

Åsa Sullivan,1 Aino Fianu-Jonasson,2 Britt-Marie Landgren,2 and Carl Erik Nord1*

Divisions of Clinical Bacteriology,1 Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden2

Received 2 August 2004/ Returned for modification 10 September 2004/ Accepted 16 September 2004

The knowledge of the effects of antimicrobial agents on the normal vaginal microflora is limited. The objective of the present study was to study the ecological impact of pivmecillinam on the normal vaginal microflora. In 20 healthy women, the estimated day of ovulation was determined during three subsequent menstrual cycles. Microbiological and clinical examinations were performed on the estimated day of ovulation and on day 3 in all cycles and also on day 7 after ovulation in cycles 1 and 2. Anaerobic and facultative anaerobic gram-positive rods, mainly species of lactobacilli and actinomycetes, dominated the microflora. One woman was colonized on the third day of administration with a resistant Escherichia coli strain, and Candida albicans was detected in one woman on days 3 and 7 in cycle 2. No other major changes in the normal microflora occurred during the study. Administration of pivmecillinam had a minor ecological impact on the normal vaginal microflora.

* Corresponding author. Mailing address: Division of Clinical Bacteriology, F82, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden. Phone: 46 8 585 878 38. Fax: 46 8 711 3918. E-mail: carl.erik.nord{at}labmed.ki.se.

Antimicrobial Agents and Chemotherapy, January 2005, p. 170-175, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.170-175.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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