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Antimicrobial Agents and Chemotherapy, January 2005, p. 406-407, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.406-407.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Serine-to-Asparagine Substitution in the GyrA Gene Leads to Quinolone Resistance in Moxifloxacin-Exposed Chlamydia pneumoniae

Jan Rupp,1 Andreas Gebert,2 Werner Solbach,1 and Matthias Maass1*

Institute of Medical Microbiology and Hygiene,1 Institute of Anatomy University of Luebeck, Luebeck, Germany2

Received 2 August 2004/ Returned for modification 12 August 2004/ Accepted 7 September 2004

Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a Ser->Asn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany. Phone: 49 (0)451 500 2822. Fax: 49 (0)451 500 2808. E-mail: matthias.maass{at}ukl.uni-luebeck.de.

Antimicrobial Agents and Chemotherapy, January 2005, p. 406-407, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.406-407.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Binet, R., Maurelli, A. T. (2005). Frequency of Spontaneous Mutations That Confer Antibiotic Resistance in Chlamydia spp.. Antimicrob. Agents Chemother. 49: 2865-2873 [Abstract] [Full Text]  


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