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Antimicrobial Agents and Chemotherapy, January 2005, p. 406-407, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.406-407.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Serine-to-Asparagine Substitution in the GyrA Gene Leads to Quinolone Resistance in Moxifloxacin-Exposed Chlamydia pneumoniae

Institute of Medical Microbiology and Hygiene,¹ Institute of Anatomy University of Luebeck, Luebeck, Germany²

Received 2 August 2004/ Returned for modification 12 August 2004/ Accepted 7 September 2004

Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a SerAsn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.

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