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Antimicrobial Agents and Chemotherapy, January 2005, p. 414-417, Vol. 49, No. 1
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.1.414-417.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
dfrA20, a Novel Trimethoprim Resistance Gene from Pasteurella multocida
Corinna Kehrenberg and
Stefan Schwarz*
Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Neustadt-Mariensee, Germany
Received 23 April 2004/
Returned for modification 16 July 2004/
Accepted 18 September 2004
A novel trimethoprim resistance gene, designated dfrA20, was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. The dfrA20 gene codes for a dihydrofolate reductase of 169 amino acids. Sequence comparisons revealed that the DfrA20 protein differed distinctly from all dihydrofolate reductases known so far.
* Corresponding author. Mailing address: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystr. 10, 31535 Neustadt-Mariensee, Germany. Phone: 49-5034-871-241. Fax: 49-5034-871-246. E-mail: stefan.schwarz{at}fal.de.
Antimicrobial Agents and Chemotherapy, January 2005, p. 414-417, Vol. 49, No. 1
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.1.414-417.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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