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Antimicrobial Agents and Chemotherapy, January 2005, p. 418-420, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.418-420.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Streptococcus pyogenes Pharyngeal Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Mechanisms of Resistance and Clonal Diversity

Sebastián Albertí,^1* Guadalupe Cortés,¹ Cesar García-Rey,² Carmen Rubio,³ Fernando Baquero,⁴ José Ángel García-Rodríguez,⁵ Emilio Bouza,⁶ Lorenzo Aguilar,² and the Spanish Surveillance Group for Respiratory Pathogens

Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), Universitat de les Illes Balears (UIB), Palma de Mallorca,¹ Departamento Médico, GlaxoSmithKline, Tres Cantos,² Servicio de Microbiología, Hospital Lozano Blesa, Zaragoza,³ Servicio de Microbiología, Hospital Ramón y Cajal,⁴ Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid,⁶ Servicio de Microbiología, Hospital Clínico, Salamanca, Spain⁵

Received 13 April 2004/ Returned for modification 5 August 2004/ Accepted 23 September 2004

A survey of emm gene sequences and an analysis of the pulsed-field electrophoretic profiles of 30 Streptococcus pyogenes isolates with reduced susceptibilities to ciprofloxacin detected the prevalence of isolates with emm type 6 and considerable genetic diversity among isolates. The mechanism of ciprofloxacin resistance in these isolates was based on point mutations in topoisomerase IV subunit C encoded by parC, mainly replacement of serine-79 by alanine.

Participants in the Spanish Surveillance Group for Respiratory Pathogens are listed in Acknowledgments.

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