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Antimicrobial Agents and Chemotherapy, January 2005, p. 421-424, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.421-424.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Increased Expression of Two Multidrug Transporter-Like Genes Is Associated with Ethidium Bromide and Ciprofloxacin Resistance in Mycoplasma hominis

S. Raherison, P. Gonzalez, H. Renaudin, A. Charron, C. Bébéar, and C. M. Bébéar*

Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bordeaux Cedex, France

Received 6 April 2004/ Returned for modification 11 July 2004/ Accepted 11 September 2004

Two genes, md1 and md2, coding for multidrug resistance ATP-binding cassette transporters were identified in Mycoplasma hominis PG21. Expression of these two genes, quantified by quantitative competitive reverse transcription-PCR, was significantly increased in ethidium bromide-resistant strains of M. hominis compared to that in M. hominis PG21.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Phone: (33) 5.57.57.16.25. Fax: (33) 5.56.93.29.40. E-mail: cecile.bebear{at}u-bordeaux2.fr.

Antimicrobial Agents and Chemotherapy, January 2005, p. 421-424, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.421-424.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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