This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Manavathu, E. K.
Right arrow Articles by Chandrasekar, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Manavathu, E. K.
Right arrow Articles by Chandrasekar, P. H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2005, p. 428-430, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.428-430.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vivo Resistance of a Laboratory-Selected Aspergillus fumigatus Isolate to Amphotericin B

Elias K. Manavathu,* Jessica L. Cutright, and Pranatharthi H. Chandrasekar

Division of Infectious Diseases, Department of Internal Medicine, Wayne State University, Detroit, Michigan

Received 31 March 2004/ Returned for modification 13 May 2004/ Accepted 16 September 2004

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

* Corresponding author. Mailing address: 427 Lande Building, Wayne State University, 550 E. Canfield, Detroit, MI 48201. Phone: (313) 577-1931. Fax: (313) 993-0302. E-mail: aa1388{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, January 2005, p. 428-430, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.428-430.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Beernaert, L. A., Pasmans, F., Van Waeyenberghe, L., Dorrestein, G. M., Verstappen, F., Vercammen, F., Haesebrouck, F., Martel, A. (2009). Avian Aspergillus fumigatus Strains Resistant to both Itraconazole and Voriconazole. Antimicrob. Agents Chemother. 53: 2199-2201 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»