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Antimicrobial Agents and Chemotherapy, January 2005, p. 444-446, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.444-446.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis in Brazil

Vívian de F. Sumnienski Rodrigues,1,2 Maria Alice Telles,3 Marta Osório Ribeiro,2 Patrícia Izquierdo Cafrune,2 Maria Lucia Rosa Rossetti,2 and Arnaldo Zaha1*

Centro de Biotecnologia do Estado do Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS),1 Centro de Desenvolvimento Científico e Tecnológico (CDCT), Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS), Porto Alegre,2 Laboratório de Bacteriologia da Tuberculose, Instituto Adolfo Lutz, São Paulo, Brazil3

Received 11 August 2004/ Returned for modification 1 September 2004/ Accepted 27 September 2004

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

* Corresponding author. Mailing address: Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Rua Bento Gonçalves 9500, Prédio 43421, CEP 91501-970 Porto Alegre, RS, Brazil. Phone: 55 51 3316-6054. Fax: 55 51 3316-7309. E-mail: zaha{at}cbiot.ufrgs.br.

Antimicrobial Agents and Chemotherapy, January 2005, p. 444-446, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.444-446.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jureen, P., Werngren, J., Toro, J.-C., Hoffner, S. (2008). Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52: 1852-1854 [Abstract] [Full Text]  
  • Barco, P., Cardoso, R. F., Hirata, R. D. C., Leite, C. Q. F., Pandolfi, J. R., Sato, D. N., Shikama, M. L., de Melo, F. F., Mamizuka, E. M., Campanerut, P. A. Z., Hirata, M. H. (2006). pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil. J Antimicrob Chemother 58: 930-935 [Abstract] [Full Text]  


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