AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rodrigues, V. d. F. S.
Right arrow Articles by Zaha, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rodrigues, V. d. F. S.
Right arrow Articles by Zaha, A.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2005, p. 444-446, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.444-446.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis in Brazil

Vívian de F. Sumnienski Rodrigues,1,2 Maria Alice Telles,3 Marta Osório Ribeiro,2 Patrícia Izquierdo Cafrune,2 Maria Lucia Rosa Rossetti,2 and Arnaldo Zaha1*

Centro de Biotecnologia do Estado do Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS),1 Centro de Desenvolvimento Científico e Tecnológico (CDCT), Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS), Porto Alegre,2 Laboratório de Bacteriologia da Tuberculose, Instituto Adolfo Lutz, São Paulo, Brazil3

Received 11 August 2004/ Returned for modification 1 September 2004/ Accepted 27 September 2004

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

* Corresponding author. Mailing address: Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Rua Bento Gonçalves 9500, Prédio 43421, CEP 91501-970 Porto Alegre, RS, Brazil. Phone: 55 51 3316-6054. Fax: 55 51 3316-7309. E-mail: zaha{at}cbiot.ufrgs.br.

Antimicrobial Agents and Chemotherapy, January 2005, p. 444-446, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.444-446.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2005 by the American Society for Microbiology. All rights reserved.