Previous Article | Next Article ![]()
Antimicrobial Agents and Chemotherapy, January 2005, p. 444-446, Vol. 49, No. 1
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.1.444-446.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Centro de Biotecnologia do Estado do Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS),1 Centro de Desenvolvimento Científico e Tecnológico (CDCT), Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS), Porto Alegre,2 Laboratório de Bacteriologia da Tuberculose, Instituto Adolfo Lutz, São Paulo, Brazil3
Received 11 August 2004/ Returned for modification 1 September 2004/ Accepted 27 September 2004
In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.
This article has been cited by other articles:
Copyright © 2009 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»