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Antimicrobial Agents and Chemotherapy, January 2005, p. 451-453, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.451-453.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of In100, a New Integron Carrying a Metallo-ß-Lactamase and a Carbenicillinase, from Pseudomonas aeruginosa

Sandra Quinteira,1,2 João Carlos Sousa,1 and Luísa Peixe1*

Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto,1 Escola Superior de Saúde do Vale do Ave, Vila Nova de Famalicão, Portugal2

Received 19 April 2004/ Returned for modification 14 July 2004/ Accepted 11 September 2004

In100, a new integron carrying a carbapenemase gene (blaVIM-2) associated with a carbenicillinase (blaP1b) and aminoglycoside resistance genes (aacA4 and aadA2), was detected in a Pseudomonas aeruginosa clinical isolate. The particular gene cassette organization of In100 seems to reflect the evolution of antibiotic usage in therapeutics.

* Corresponding author. Mailing address: Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164 4050-047 Porto, Portugal. Phone: 351-222078946. Fax: 351-222003977. E-mail: lpeixe{at}ff.up.pt.

Antimicrobial Agents and Chemotherapy, January 2005, p. 451-453, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.451-453.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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