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Antimicrobial Agents and Chemotherapy, January 2005, p. 454-456, Vol. 49, No. 1
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.1.454-456.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Relationship between Copper, Glycopeptide, and Macrolide Resistance among Enterococcus faecium Strains Isolated from Pigs in Denmark between 1997 and 2003
Henrik Hasman* and
Frank M. Aarestrup
Danish Institute for Food and Veterinary Research, Copenhagen, Denmark
Received 6 May 2004/
Returned for modification 16 August 2004/
Accepted 29 August 2004
A significant relationship between copper resistance (tcrB), glycopeptide resistance (Tn1546), and macrolide resistance [erm(B)] in Enterococcus faecium isolated from pigs was found. The tcrB gene was located closely upstream of the Tn1546 element. However, the continued use of copper sulfate has not been able to maintain high levels of macrolide and glycopeptide resistance.
* Corresponding author. Mailing address: Danish Institute for Food and Veterinary Research, Bülowsvej 27, DK-1790 Copenhagen V, Denmark. Phone: (45) 72 34 63 47. Fax: (45) 72 34 63 41. E-mail: hha{at}dfvf.dk.
Antimicrobial Agents and Chemotherapy, January 2005, p. 454-456, Vol. 49, No. 1
0066-4804/05/$08.00+0 doi:10.1128/AAC.49.1.454-456.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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Copyright © 2005 by the American Society for Microbiology. All rights reserved.