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Antimicrobial Agents and Chemotherapy, January 2005, p. 464-466, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.464-466.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Influence of Carbon Dioxide on the MIC of Telithromycin for Streptococcus pneumoniae: an In Vitro-In Vivo Study

Eric Batard,1* Marie Emmanuelle Juvin,2 Cédric Jacqueline,1 Denis Bugnon,1 Jocelyne Caillon,1,2 Gilles Potel,1 and Henri B. Drugeon1,2

Laboratoire d'Antibiologie, Faculté de Médecine,1 Laboratoire de Bactériologie Centre Hospitalier et Universitaire, Nantes, France2

Received 24 April 2004/ Returned for modification 23 June 2004/ Accepted 10 September 2004

Incubation in CO2 resulted in higher (≥3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO2 was not correlated with loss of its activity in the murine sepsis/peritonitis model.

* Corresponding author. Mailing address: Laboratoire d'Antibiologie (UPRES EA-1156), UER de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France. Phone and Fax: 33-240-41-2854. E-mail: ebatard{at}chu-nantes.fr.

Antimicrobial Agents and Chemotherapy, January 2005, p. 464-466, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.464-466.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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