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Antimicrobial Agents and Chemotherapy, October 2005, p. 4335-4338, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4335-4338.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis

Christine M. Johnson,1* Rajesh Pandey,2 Sadhna Sharma,2 G. K. Khuller,2 Randall J. Basaraba,1 Ian M. Orme,1 and Anne J. Lenaerts1

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523,1 Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh-160 012, India2

Received 28 April 2005/ Returned for modification 26 May 2005/ Accepted 2 August 2005

We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.

* Corresponding author. Mailing address: Colorado State University, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523-1682. Phone: (970) 491-4877. Fax: (970) 491-5125. E-mail: christine.johnson{at}colostate.edu.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4335-4338, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4335-4338.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hoff, D. R., Caraway, M. L., Brooks, E. J., Driver, E. R., Ryan, G. J., Peloquin, C. A., Orme, I. M., Basaraba, R. J., Lenaerts, A. J. (2008). Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52: 4137-4140 [Abstract] [Full Text]  
  • Hall, P. R., Hjelle, B., Brown, D. C., Ye, C., Bondu-Hawkins, V., Kilpatrick, K. A., Larson, R. S. (2008). Multivalent Presentation of Antihantavirus Peptides on Nanoparticles Enhances Infection Blockade. Antimicrob. Agents Chemother. 52: 2079-2088 [Abstract] [Full Text]  
  • Lenaerts, A. J., Hoff, D., Aly, S., Ehlers, S., Andries, K., Cantarero, L., Orme, I. M., Basaraba, R. J. (2007). Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910. Antimicrob. Agents Chemother. 51: 3338-3345 [Abstract] [Full Text]  
  • Ordway, D., Palanisamy, G., Henao-Tamayo, M., Smith, E. E., Shanley, C., Orme, I. M., Basaraba, R. J. (2007). The Cellular Immune Response to Mycobacterium tuberculosis Infection in the Guinea Pig. J. Immunol. 179: 2532-2541 [Abstract] [Full Text]  
  • Pandey, R., Khuller, G. K. (2006). Oral nanoparticle-based antituberculosis drug delivery to the brain in an experimental model. J Antimicrob Chemother 57: 1146-1152 [Abstract] [Full Text]  


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