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Antimicrobial Agents and Chemotherapy, October 2005, p. 4335-4338, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4335-4338.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis

Christine M. Johnson,^1* Rajesh Pandey,² Sadhna Sharma,² G. K. Khuller,² Randall J. Basaraba,¹ Ian M. Orme,¹ and Anne J. Lenaerts¹

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523,¹ Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh-160 012, India²

Received 28 April 2005/ Returned for modification 26 May 2005/ Accepted 2 August 2005

We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.

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* Corresponding author. Mailing address: Colorado State University, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523-1682. Phone: (970) 491-4877. Fax: (970) 491-5125. E-mail: christine.johnson{at}colostate.edu.

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Antimicrobial Agents and Chemotherapy, October 2005, p. 4335-4338, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4335-4338.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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