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Antimicrobial Agents and Chemotherapy, October 2005, p. 4339-4343, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4339-4343.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Epigallocatechin Gallate Inhibits Biofilm Formation by Ocular Staphylococcal Isolates

Anna Rita Blanco,1 Andrea Sudano-Roccaro,1 Giovanna Carmela Spoto,1 Antonia Nostro,2 and Dario Rusciano1*

Direzione Ricerca Sviluppo & Innovazione, SIFI SpA, Catania, Italy,1 Pharmaco-Biological Department, Section of Microbiology, Faculty of Pharmacy, University of Messina, Messina, Italy2

Received 22 April 2005/ Returned for modification 22 May 2005/ Accepted 30 June 2005

Epigallocatechin gallate (EGCg), the main polyphenol component of green tea, has several antibacterial properties. Here we show that sub-MICs of EGCg appear to decrease slime production, therefore inhibiting biofilm formation by ocular staphylococcal isolates previously characterized for the presence of ica genes by the Congo red agar plate assay and for adhesion to microtiter plates.

* Corresponding author. Mailing address: SIFI SpA, Via E. Patti 36, 95020 Lavinaio, Catania, Italy. Phone: 39095 7922 240. Fax: 39095 7922 414. E-mail: dario_rusciano{at}sifi.it.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4339-4343, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4339-4343.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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