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Antimicrobial Agents and Chemotherapy, October 2005, p. 4344-4346, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4344-4346.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efficacy of Telavancin (TD-6424), a Rapidly Bactericidal Lipoglycopeptide with Multiple Mechanisms of Action, in a Murine Model of Pneumonia Induced by Methicillin-Resistant Staphylococcus aureus

Noe Reyes, Robert Skinner, Koné Kaniga,{dagger} Kevin M. Krause, Josephine Shelton, Glenmar P. Obedencio, Alexander Gough, Michael Conner, and Sharath S. Hegde*

Theravance, Inc., 901 Gateway Blvd., South San Francisco, California 94080

Received 17 March 2005/ Returned for modification 15 May 2005/ Accepted 6 July 2005

The efficacy of telavancin, a bactericidal lipoglycopeptide, was compared to that of vancomycin and linezolid against methicillin-resistant Staphylococcus aureus (MRSA) in a murine pneumonia model. Telavancin produced greater reductions in lung bacterial titer and mortality than did vancomycin and linezolid at human doses equivalent to those described by the area under the concentration-time curve. These results suggest the potential utility of telavancin for treatment of MRSA pneumonia.

* Corresponding author. Mailing address: Theravance, Inc., 901 Gateway Blvd., South San Francisco, CA 94087. Phone: (650) 808-6432. Fax: (650) 808-6441. E-mail: shegde{at}theravance.com.

{dagger} Present address: Peninsula Pharmaceuticals, Inc., 1900 Charleston Rd., Mountain View, Ca 94043.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4344-4346, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4344-4346.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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