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Antimicrobial Agents and Chemotherapy, October 2005, p. 4354-4357, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4354-4357.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi

Kendal M. Galbraith,{dagger} Amanda C. Ng, Betsy J. Eggers,{ddagger} Craig R. Kuchel, Christian H. Eggers,§ and D. Scott Samuels*

Division of Biological Sciences, The University of Montana, Missoula, Montana 59812

Received 26 May 2005/ Returned for modification 29 June 2005/ Accepted 29 July 2005

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

* Corresponding author. Mailing address: Division of Biological Sciences, The University of Montana, 32 Campus Dr. 4824, Missoula, MT 59812-4824. Phone: (406) 243-6145. Fax: (406) 243-4304. E-mail: scott.samuels{at}umontana.edu.

{dagger} Present address: Department of Medical Microbiology & Immunology, University of Wisconsin, Madison, WI 53706.

{ddagger} Present address: Department of Virology, Bristol-Myers Squibb Company, Wallingford, CT 06492.

§ Present address: Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, CT 06030.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4354-4357, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4354-4357.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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