This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Su, X.-Z.
Right arrow Articles by Tsuchiya, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Su, X.-Z.
Right arrow Articles by Tsuchiya, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2005, p. 4362-4364, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4362-4364.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

AbeM, an H+-Coupled Acinetobacter baumannii Multidrug Efflux Pump Belonging to the MATE Family of Transporters

Xian-Zhong Su, Jing Chen, Tohru Mizushima,{dagger} Teruo Kuroda, and Tomofusa Tsuchiya*

Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan

Received 12 March 2005/ Returned for modification 24 April 2005/ Accepted 30 June 2005

We cloned a gene, abeM, for a multidrug efflux pump from Acinetobacter baumannii using Escherichia coli as the host. Sequence analysis revealed that AbeM is a member of the MATE family of pumps. AbeM was found to be an H+-coupled multidrug efflux pump and a unique member of the MATE family.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan. Phone and fax: 81-86-251-7957. E-mail: tsuchiya{at}pharm.okayama-u.ac.jp.

{dagger} Present address: Graduate School of Medical and Pharmaceutical Sciences. Kumamoto University, Kumamoto 862-0973, Japan.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4362-4364, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4362-4364.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chen, Y., Pi, B., Zhou, H., Yu, Y., Li, L. (2009). Triclosan resistance in clinical isolates of Acinetobacter baumannii. J Med Microbiol 58: 1086-1091 [Abstract] [Full Text]  
  • Beceiro, A., Perez, A., Fernandez-Cuenca, F., Martinez-Martinez, L., Pascual, A., Vila, J., Rodriguez-Bano, J., Cisneros, J. M., Pachon, J., Bou, G., and the Spanish Group for Nosocomial Infection (GE, (2009). Genetic Variability among ampC Genes from Acinetobacter Genomic Species 3. Antimicrob. Agents Chemother. 53: 1177-1184 [Abstract] [Full Text]  
  • Adams, M. D., Goglin, K., Molyneaux, N., Hujer, K. M., Lavender, H., Jamison, J. J., MacDonald, I. J., Martin, K. M., Russo, T., Campagnari, A. A., Hujer, A. M., Bonomo, R. A., Gill, S. R. (2008). Comparative Genome Sequence Analysis of Multidrug-Resistant Acinetobacter baumannii. J. Bacteriol. 190: 8053-8064 [Abstract] [Full Text]  
  • Long, F., Rouquette-Loughlin, C., Shafer, W. M., Yu, E. W. (2008). Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob. Agents Chemother. 52: 3052-3060 [Abstract] [Full Text]  
  • Bratu, S., Landman, D., Martin, D. A., Georgescu, C., Quale, J. (2008). Correlation of Antimicrobial Resistance with {beta}-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of Acinetobacter baumannii Endemic to New York City. Antimicrob. Agents Chemother. 52: 2999-3005 [Abstract] [Full Text]  
  • Peleg, A. Y., Seifert, H., Paterson, D. L. (2008). Acinetobacter baumannii: Emergence of a Successful Pathogen. Clin. Microbiol. Rev. 21: 538-582 [Abstract] [Full Text]  
  • Matsuo, T., Hayashi, K., Morita, Y., Koterasawa, M., Ogawa, W., Mizushima, T., Tsuchiya, T., Kuroda, T. (2007). VmeAB, an RND-type multidrug efflux transporter in Vibrio parahaemolyticus. Microbiology 153: 4129-4137 [Abstract] [Full Text]  
  • Hu, W. S., Yao, S.-M., Fung, C.-P., Hsieh, Y.-P., Liu, C.-P., Lin, J.-F. (2007). An OXA-66/OXA-51-Like Carbapenemase and Possibly an Efflux Pump Are Associated with Resistance to Imipenem in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51: 3844-3852 [Abstract] [Full Text]  
  • Perez, F., Hujer, A. M., Hujer, K. M., Decker, B. K., Rather, P. N., Bonomo, R. A. (2007). Global Challenge of Multidrug-Resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 51: 3471-3484 [Full Text]  
  • Vila, J., Marti, S., Sanchez-Cespedes, J. (2007). Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. J Antimicrob Chemother 59: 1210-1215 [Abstract] [Full Text]  
  • Pannek, S., Higgins, P. G., Steinke, P., Jonas, D., Akova, M., Bohnert, J. A., Seifert, H., Kern, W. V. (2006). Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-{beta}-naphthylamide. J Antimicrob Chemother 57: 970-974 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»