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Antimicrobial Agents and Chemotherapy, October 2005, p. 4365-4367, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4365-4367.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efficacy of 2-(3,4-Dimethyl-2,5-Dihydro-1H-Pyrrole-2-yl)-1-Methylethyl Pentanoate in a Murine Model of Invasive Aspergillosis

Rajesh Dabur,1 S. K. Diwedi,1 V. Yadav,3 V. Mishra,4 Rambir Singh,1 H. Singh,2 and G. L. Sharma3*

Institute of Biomedical Sciences, Bundelkhand University, Jhansi-284128, India,1 Department of Biochemistry, Kurukshetra University, Kurukshetra-136119, India,2 Institute of Genomics and Integrative Biology, Mall Road, Delhi University Campus, Delhi-110007, India,3 Department of Microbiology, Bundelkhand University, Jhansi-284128, India4

Received 6 May 2005/ Returned for modification 9 June 2005/ Accepted 11 July 2005

2-(3,4-Dimethyl-2,5-dihydro-1H-pyrrole-2-yl)-1-methylethyl pentanoate, an antifungal compound, was found to be nontoxic to RAW cells up to a concentration of 312.5 µg/ml, whereas amphotericin B was lethal to all cells at 37.5 µg/ml. The treatment of Aspergillus fumigatus-infected mice with a dose of 200.0 mg of compound/kg of body weight increased their survival rate by 60%, with a decrease in CFU in organ tissues. The protection afforded by the compound against experimental aspergillosis was found to be dose dependent.

* Corresponding author. Mailing address: Institute of Genomics and Integrative Biology, Mall Road, Delhi University Campus, Delhi-110007, India. Phone: 91-517-2321180. Fax: 91-517-2320761. E-mail: drglsharma{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4365-4367, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4365-4367.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dabur, R., Mandal, T. K., Sharma, G. L. (2007). Post-antifungal effects of the antifungal compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate on Aspergillus fumigatus. J Med Microbiol 56: 815-818 [Abstract] [Full Text]  


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