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Antimicrobial Agents and Chemotherapy, October 2005, p. 4368-4371, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4368-4371.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Penetration of Piperacillin and Tazobactam into Inflamed Soft Tissue of Patients with Diabetic Foot Infection

F. J. Legat,1* R. Krause,2 P. Zenahlik,1 C. Hoffmann,1 S. Scholz,1 W. Salmhofer,1 J. Tscherpel,1 T. Tscherpel,1 H. Kerl,1 and P. Dittrich3

Department of Dermatology,1 Department of Medicine, Division of Infectious Diseases, Medical University of Graz, Auenbruggerplatz 2, A-8036 Graz,2 Institute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology, Karl-Franzens-University of Graz, Universitaetsplatz 2, A-8010 Graz, Austria3

Received 20 April 2005/ Returned for modification 29 May 2005/ Accepted 18 July 2005

We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.

* Corresponding author. Mailing address: Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria. Phone: 43-316-385-3012. Fax: 43-316-385-2466. E-mail: franz.legat{at}meduni-graz.at.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4368-4371, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4368-4371.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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