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Antimicrobial Agents and Chemotherapy, October 2005, p. 4372-4374, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4372-4374.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Activity of Ceftobiprole against Staphylococci Displaying Normal and Small-Colony Variant Phenotypes

Christof von Eiff,1* Alexander W. Friedrich,2 Karsten Becker,1 and Georg Peters1

Institute of Medical Microbiology,1 Institute of Hygiene, University of Münster Hospital and Clinics, 48149 Münster, Germany2

Received 20 May 2005/ Returned for modification 19 July 2005/ Accepted 26 July 2005

The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by ≤2 µg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.

* Corresponding author. Mailing address: Institute of Medical Microbiology, University of Münster Hospital and Clinics, Domagkstraße 10, 48149 Münster, Germany. Phone: 49-251-835-5360. Fax: 49-251-835-5350. E-mail: eiffc{at}uni-muenster.de.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4372-4374, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4372-4374.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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