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Antimicrobial Agents and Chemotherapy, October 2005, p. 4379-4381, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4379-4381.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Macrolide Resistance Mediated by a Bifidobacterium breve Membrane Protein

Abelardo Margolles,1* José Antonio Moreno,1,2 Douwe van Sinderen,2 and Clara G. de los Reyes-Gavilán1

Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas, Ctra. Infiesto s/n, 33300, Villaviciosa, Asturias, Spain,1 Alimentary Pharmabiotic Centre, Department of Microbiology, University College Cork, Western Road, Cork, Ireland2

Received 7 April 2005/ Returned for modification 24 June 2005/ Accepted 14 July 2005

A gene coding for a hypothetical membrane protein from Bifidobacterium breve was expressed in Lactococcus lactis. Immunoblotting demonstrated that this protein is located in the membrane. Phenotypical changes in sensitivity towards 21 antibiotics were determined. The membrane protein-expressing cells showed higher levels of resistance to several macrolides.

* Corresponding author. Mailing address: Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (CSIC), Ctra. Infiesto s/n, 33300, Villaviciosa, Asturias, Spain. Phone: 34 985 89 21 31. Fax: 34 985 89 22 33. E-mail: amargolles{at}ipla.csic.es.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4379-4381, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4379-4381.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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