This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Boffito, M. Articles by Shah, J. Search for Related Content PubMed PubMed Citation Articles by Boffito, M. Articles by Shah, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2005, p. 4386-4389, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4386-4389.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Lack of Pharmacokinetic Drug Interaction between Tenofovir Disoproxil Fumarate and Nelfinavir Mesylate

PK Research, Chelsea and Westminster Hospital, London, United Kingdom,¹ Gilead Sciences, Inc., Foster City, California²

Received 24 March 2005/ Returned for modification 31 May 2005/ Accepted 12 July 2005

A study explored the pharmacokinetics of tenofovir (300 mg administered once daily) and nelfinavir (1,250 mg twice daily) when coadministered in 29 healthy volunteers. Tenofovir, nelfinavir, and M8 pharmacokinetics was unaltered when tenofovir and nelfinavir were coadministered, and tenofovir administration did not affect the M8/nelfinavir area under the concentration-versus-time curve over the dosing interval (AUC_tau) ratio. No interaction between tenofovir and nelfinavir was observed.

This article has been cited by other articles:

• Tong, L., Phan, T. K., Robinson, K. L., Babusis, D., Strab, R., Bhoopathy, S., Hidalgo, I. J., Rhodes, G. R., Ray, A. S. (2007). Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro. Antimicrob. Agents Chemother. 51: 3498-3504 [Abstract] [Full Text]  
• Chittick, G. E., Zong, J., Blum, M. R., Sorbel, J. J., Begley, J. A., Adda, N., Kearney, B. P. (2006). Pharmacokinetics of tenofovir disoproxil fumarate and ritonavir-boosted saquinavir mesylate administered alone or in combination at steady state.. Antimicrob. Agents Chemother. 50: 1304-1310 [Abstract] [Full Text]