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Antimicrobial Agents and Chemotherapy, October 2005, p. 4390-4392, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4390-4392.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Contribution of Mutation at Amino Acid 45 of AcrR to acrB Expression and Ciprofloxacin Resistance in Clinical and Veterinary Escherichia coli Isolates

Mark A. Webber, Ashraf Talukder, and Laura J. V. Piddock*

Antimicrobial Agents Research Group, Division of Immunity and Infection, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom

Received 23 May 2005/ Returned for modification 1 July 2005/ Accepted 21 July 2005

Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

* Corresponding author. Mailing address: Antimicrobial Agents Research Group, Division of Immunity and Infection, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom. Phone: 44 121 414 6966. Fax: 44 121 414 6815. E-mail: l.j.v.piddock{at}bham.ac.uk.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4390-4392, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4390-4392.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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