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Antimicrobial Agents and Chemotherapy, October 2005, p. 4396-4399, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4396-4399.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks

John Casey,1* Paul J. Cote,2 Illia A. Toshkov,3 Chung K. Chu,4 John L. Gerin,2 William E. Hornbuckle,3 Bud C. Tennant,3 and Brent E. Korba2

Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D.C.,1 Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland,2 Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York,3 College of Pharmacy, University of Georgia, Athens, Georgia4

Received 10 March 2005/ Returned for modification 26 May 2005/ Accepted 14 July 2005

In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057. Phone: (202) 687-1052. Fax: (202) 687-1800. E-mail: caseyj{at}georgetown.edu.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4396-4399, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4396-4399.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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