AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adediran, S. A.
Right arrow Articles by Pratt, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adediran, S. A.
Right arrow Articles by Pratt, R. F.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2005, p. 4410-4412, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4410-4412.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Inhibition of Class D ß-Lactamases by Acyl Phosphates and Phosphonates

S. A. Adediran,1 Michiyoshi Nukaga,2 Stéphane Baurin,3 J.-M. Frère,3 and R. F. Pratt1*

Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459,1 Faculty of Pharmaceutical Sciences, Jyosai International University, 1 Gumyo, Togane-shi, Chiba 283-8555, Japan,2 Centre d'Ingeniere des Proteines et Laboratoire d'Enzymologie, Université de Liège, B-4000 Sart Tilman, Liège 1, Belgium3

Received 6 April 2005/ Returned for modification 15 June 2005/ Accepted 29 July 2005

The susceptibility of typical class D ß-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM ß-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.

* Corresponding author. Mailing address: Department of Chemistry, Wesleyan University, Middletown, CT 06459. Phone: (860) 685-2629. Fax: (860) 685-2211. E-mail: rpratt{at}wesleyan.edu.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4410-4412, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4410-4412.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2005 by the American Society for Microbiology. All rights reserved.