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Antimicrobial Agents and Chemotherapy, October 2005, p. 4410-4412, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4410-4412.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Inhibition of Class D ß-Lactamases by Acyl Phosphates and Phosphonates

S. A. Adediran,1 Michiyoshi Nukaga,2 Stéphane Baurin,3 J.-M. Frère,3 and R. F. Pratt1*

Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459,1 Faculty of Pharmaceutical Sciences, Jyosai International University, 1 Gumyo, Togane-shi, Chiba 283-8555, Japan,2 Centre d'Ingeniere des Proteines et Laboratoire d'Enzymologie, Université de Liège, B-4000 Sart Tilman, Liège 1, Belgium3

Received 6 April 2005/ Returned for modification 15 June 2005/ Accepted 29 July 2005

The susceptibility of typical class D ß-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM ß-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.

* Corresponding author. Mailing address: Department of Chemistry, Wesleyan University, Middletown, CT 06459. Phone: (860) 685-2629. Fax: (860) 685-2211. E-mail: rpratt{at}wesleyan.edu.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4410-4412, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4410-4412.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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