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Antimicrobial Agents and Chemotherapy, October 2005, p. 4413-4417, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4413-4417.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Doripenem and Comparator Agents against 364 Anaerobic Clinical Isolates

Hannah M. Wexler,1,2* Adrian E. Engel,1 Daniel Glass,1 and Calida Li1

Medical and Research Services, Greater Los Angeles Veterans Administration Health Care Services, Los Angeles, California,1 Department of Medicine, UCLA School of Medicine, Los Angeles, California2

Received 21 April 2005/ Returned for modification 29 May 2005/ Accepted 25 July 2005

The in vitro activities of doripenem against 364 anaerobic isolates were measured and compared to those of ertapenem, imipenem, meropenem, ceftriaxone, and levofloxacin. All of the carbapenems were active against nearly all Bacteroides fragilis group isolates. Doripenem was either comparable to or slightly less active than imipenem and meropenem against most isolates but more active than the other penems against Clostridium difficile. Doripenem appears to have excellent activity against a broad range of anaerobes.

* Corresponding author. Mailing address: Wadsworth Anaerobe Laboratory, Bldg. 304, Room E3-224, GLAVAHCS 691/151J, Los Angeles, CA 90073. Phone: (310) 268-3404. Fax: (310) 268-4458. E-mail: hwexler{at}ucla.edu.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4413-4417, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4413-4417.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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