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Antimicrobial Agents and Chemotherapy, November 2005, p. 4667-4670, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4667-4670.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Virulence Factors of Escherichia coli Isolates That Produce CTX-M-Type Extended-Spectrum ß-Lactamases

Johann D. D. Pitout,1,2,5* Kevin B. Laupland,1,3,4 Deirdre L. Church,1,3,5 Megan L. Menard,6 and James R. Johnson6,7

Departments of Pathology and Laboratory Medicine,1 Microbiology and Infectious Diseases,2 Medicine,3 Critical Care Medicine, University of Calgary,4 Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada,5 Mucosal and Vaccine Research Center, Veterans Affairs Medical Center,6 Department of Medicine, University of Minnesota, Minneapolis, Minnesota7

Received 22 June 2005/ Returned for modification 12 August 2005/ Accepted 19 August 2005

This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum ß-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phylogenic group D; 67% of the CTX-M-15 producers were from group B2. A single CTX-M-14-producing strain belonged to clonal group A. There were significant prevalence differences for individual virulence factors among CTX-M producers and nonproducers; however, aggregate virulence factor scores were similar. CTX-M producers more commonly caused repeat urinary tract infections. Our results indicate that CTX-M type predicts phylogenetic background, and the virulence potential of ESBL-producing E. coli isolates is a complex issue, requiring further study and ongoing surveillance.

* Corresponding author. Mailing address: Division of Microbiology, Calgary Laboratory Services, #9, 3535 Research Rd. NW, Calgary, Alberta, Canada T2L 2K8. Phone: (403) 770-3309. Fax: (403) 770-3347. E-mail: johann.pitout{at}cls.ab.ca.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4667-4670, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4667-4670.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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