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Antimicrobial Agents and Chemotherapy, November 2005, p. 4751-4753, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4751-4753.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Combination Therapy with Terbinafine and Amphotericin B in a Rabbit Model of Experimental Invasive Aspergillosis

William R. Kirkpatrick,1* Ana C. Vallor,1 Robert K. McAtee,1 Neil S. Ryder,4 Annette W. Fothergill,2 Michael G. Rinaldi,2,3 and Thomas F. Patterson1,3

Departments of Medicine,1 Pathology, The University of Texas Health Science Center at San Antonio, Texas 78229-3900,2 Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78284,3 Novartis Institutes for Biomedical Research, Inc., Cambridge, Massachusetts 017424

Received 29 December 2004/ Returned for modification 2 February 2005/ Accepted 22 August 2005

Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229-3900. Phone: (210) 567-4823. Fax: (210) 567-3303. E-mail: kirkpatrick{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4751-4753, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4751-4753.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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