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Antimicrobial Agents and Chemotherapy, November 2005, p. 4757-4759, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4757-4759.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Activities of Flucytosine, Fluconazole, Amphotericin B, and Micafungin in a Murine Model of Disseminated Infection by Candida glabrata

Marçal Mariné, Carolina Serena, Belkys Fernández-Torres, F. Javier Pastor, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 27 July 2005/ Returned for modification 22 August 2005/ Accepted 24 August 2005

We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201, Reus, Spain. Phone: 34-977-759359. Fax: 34-977-759322. E-mail: josep.guarro{at}urv.net.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4757-4759, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4757-4759.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Marine, M., Espada, R., Torrado, J., Pastor, F. J., Guarro, J. (2008). Efficacy of a new formulation of amphotericin B in a murine model of disseminated infection by Candida glabrata. J Antimicrob Chemother 61: 880-883 [Abstract] [Full Text]  
  • Marine, M., Serena, C., Pastor, F. J., Guarro, J. (2006). Combined antifungal therapy in a murine infection by Candida glabrata. J Antimicrob Chemother 58: 1295-1298 [Abstract] [Full Text]  


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