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Antimicrobial Agents and Chemotherapy, November 2005, p. 4767-4770, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4767-4770.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

TLA-2, a Novel Ambler Class A Expanded-Spectrum ß-Lactamase

Delphine Girlich,1 Laurent Poirel,1 Andreas Schlüter,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Université Paris XI, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France,1 Fakultät für Biologie, Lehrstuhl für Genetik, Universität Bielefeld, D-33615 Bielefeld, Germany2

Received 26 May 2005/ Returned for modification 26 June 2005/ Accepted 24 August 2005

ß-Lactamase TLA-2 is encoded by a 47-kb plasmid isolated from an unidentified bacterial strain from a wastewater treatment plant. TLA-2 is an Ambler class A ß-lactamase that shares 52% amino acid identity with CGA-1 from Chryseobacterium gleum and 51% with TLA-1 from Escherichia coli. The enzyme hydrolyzes mostly cephalosporins.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cédex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4767-4770, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4767-4770.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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