AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xie, Z.
Right arrow Articles by Rubin, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xie, Z.
Right arrow Articles by Rubin, E. J.
Antimicrobial Agents and Chemotherapy, November 2005, p. 4778-4780, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4778-4780.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Differential Antibiotic Susceptibilities of Starved Mycobacterium tuberculosis Isolates

Zhifang Xie, Noman Siddiqi, and Eric J. Rubin*

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts

Received 22 July 2005/ Returned for modification 5 August 2005/ Accepted 22 August 2005

We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.

* Corresponding author. Mailing address: Harvard Medical School, Armenise Bldg., Room 439, Microbiology and Molecular Genetics, 200 Longwood Avenue, Boston, MA 02115. Phone: (617) 432-3335. Fax: (617) 432-3259. E-mail: erubin{at}hsph.harvard.edu.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4778-4780, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4778-4780.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2005 by the American Society for Microbiology. All rights reserved.