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Antimicrobial Agents and Chemotherapy, November 2005, p. 4781-4783, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4781-4783.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Use of an Efflux-Deficient Streptococcus pneumoniae Strain Panel To Identify ABC-Class Multidrug Transporters Involved in Intrinsic Resistance to Antimicrobial Agents

Gregory T. Robertson, Timothy B. Doyle, and A. Simon Lynch*

Cumbre, Inc., 1502 Viceroy Drive, Dallas, Texas 75235-2304

Received 9 June 2005/ Returned for modification 1 July 2005/ Accepted 7 August 2005

Thirteen derivatives of the Streptococcus pneumoniae TIGR4 strain in which putative drug efflux pumps were genetically inactivated were constructed and characterized. The results indicate that two linked genes encoding the ABC-type transporters SP2073 and SP2075 function together to confer intrinsic resistance to a series of structurally unrelated compounds, including certain fluoroquinolones.

* Corresponding author. Mailing address: Cumbre, Inc., 1502 Viceroy Dr., Dallas, TX 75235-2304. Phone: (214) 631-4700. Fax: (214) 631-4710. E-mail: simon.lynch{at}cumbre.biz.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4781-4783, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4781-4783.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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