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Antimicrobial Agents and Chemotherapy, November 2005, p. 4787-4788, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4787-4788.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efficacy of Penicillin versus Cefdinir in Eradication of Group A Streptococci and Tonsillar Flora

Itzhak Brook1* and Perry A. Foote2

Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C.,1 Department of Otorhinolaryngology, University of Florida, Alachua General Hospital, Gainesville, Florida2

Received 4 May 2005/ Returned for modification 1 July 2005/ Accepted 21 August 2005

Core tonsillar cultures were obtained from 40 children with recurrent tonsillitis treated with either penicillin or cefdinir. Group A beta-hemolytic streptococci were isolated from 11 penicillin- and 3 cefdinir-treated (P < 0.001) patients. ß-Lactamase producers were recovered from 17 penicillin- and 3 cefdinir-treated (P < 0.01) patients. Inhibiting alpha-hemolytic streptococci were isolated less often from penicillin-treated patients than from cefdinir-treated patients.

* Corresponding author. Mailing address: 4431 Albemarle St. NW, Washington, DC 20016. Fax: (202) 244-6809. Phone: (301) 295-2698. E-mail: ib6{at}georgetown.edu.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4787-4788, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4787-4788.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Casey, J. R., Kahn, R., Gmoser, D., Atlas, E., Urbani, K., Luber, S., Pellman, H., Pichichero, M. E. (2008). Frequency of Symptomatic Relapses of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children From 4 Pediatric Practices Following Penicillin, Amoxicillin, and Cephalosporin Antibiotic Treatment. CLIN PEDIATR 47: 549-554 [Abstract]  
  • Brook, I. (2007). Penicillin Failure in the Treatment of Acute and Relapsing Tonsillopharyngitis Is Associated With Copathogens and Alteration of Microbial Balance: A Role for Cephalosporins. CLIN PEDIATR 46: 17S-24S [Abstract]  
  • Casey, J. R. (2007). Selecting the Optimal Antibiotic in the Treatment of Group A {beta}-Hemolytic Streptococci Pharyngitis. CLIN PEDIATR 46: 25S-35S [Abstract]  
  • Brook, I., Gober, A. E. (2006). Recovery of interfering and {beta}-lactamase-producing bacteria from group A {beta}-haemolytic streptococci carriers and non-carriers.. J Med Microbiol 55: 1741-1744 [Abstract] [Full Text]  


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