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Antimicrobial Agents and Chemotherapy, November 2005, p. 4789-4792, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4789-4792.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Therapeutic Effects of Bacteriophage Cpl-1 Lysin against Streptococcus pneumoniae Endocarditis in Rats

J. M. Entenza,1* J. M. Loeffler,2 D. Grandgirard,3 V. A. Fischetti,2 and P. Moreillon1

Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland,1 Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 New York Avenue, New York, New York 10021,2 Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, CH-3010 Bern, Switzerland3

Received 11 April 2005/ Returned for modification 3 June 2005/ Accepted 13 July 2005

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.

* Corresponding author. Mailing address: Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Phone: 41-21-6925600. Fax: 41-21-6925605. E-mail: Jose.Entenza{at}unil.ch.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4789-4792, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4789-4792.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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