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Antimicrobial Agents and Chemotherapy, November 2005, p. 4793-4794, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4793-4794.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Recovery of Interfering Bacteria in the Nasopharynx following Antimicrobial Therapy of Acute Maxillary Sinusitis with Telithromycin or Amoxicillin-Clavulanate

Itzhak Brook and Jeffrey N. Hausfeld*

Georgetown University School of Medicine, Washington, D.C

Received 4 June 2005/ Returned for modification 8 July 2005/ Accepted 19 August 2005

The effect on the nasopharyngeal flora of 7 days of amoxicillin-clavulanate or 5 days of 800 mg once a day was studied in 50 adults with acute sinusitis. The numbers of potential pathogens and interfering alpha-hemolytic streptococci were equally reduced after both therapies. However, the number of interfering Prevotella spp. declined more significantly after amoxicillin-clavulanate treatment.

* Corresponding author. Mailing address: 4431 Albemarle St. NW, Washington, DC 20016. Phone: (301) 295-2698. Fax: (202) 244-6809. E-mail: ib6{at}georgetown.edu/.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4793-4794, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4793-4794.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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