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Antimicrobial Agents and Chemotherapy, November 2005, p. 4795-4797, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4795-4797.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effectiveness of Anidulafungin in Eradicating Candida Species in Invasive Candidiasis

M. A. Pfaller,1,3* D. J. Diekema,1,2 L. Boyken,1 S. A. Messer,1 S. Tendolkar,1 R. J. Hollis,1 and B. P. Goldstein4

Departments of Pathology,1 Medicine,2 Epidemiology, Roy J. and Lucille A. Carver College of Medicine, College of Public Health, University of Iowa, Iowa City, Iowa 52242,3 Vicuron Pharmaceuticals Inc., King of Prussia, Pennsylvania 194064

Received 16 May 2005/ Returned for modification 8 June 2005/ Accepted 29 August 2005

In a phase 2 open-label, dose-ranging study in patients with candidemia, anidulafungin was effective in eradicating Candida albicans and other species of Candida. The anidulafungin MIC distribution showed that Candida albicans and C. glabrata were the most susceptible species and C. parapsilosis was the least susceptible species.

* Corresponding author. Mailing address: Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242. Phone: (319) 384-9566. Fax: (319) 356-4916. E-mail: michael-pfaller{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4795-4797, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4795-4797.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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