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Antimicrobial Agents and Chemotherapy, November 2005, p. 4801-4803, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4801-4803.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

New Mycobacterium avium Antifolate Shows Synergistic Effect when Used in Combination with Dihydropteroate Synthase Inhibitors

W. J. Suling,1 L. E. Seitz,1 R. C. Reynolds,1 and W. W. Barrow2*

Southern Research Institution, Birmingham, Alabama,1 Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma2

Received 20 May 2005/ Returned for modification 13 July 2005/ Accepted 29 August 2005

Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.

* Corresponding author. Mailing address: Department of Veterinary Pathobiology, 250 McElroy Hall, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078. Phone: (405) 744-1842. Fax: (405) 744-5275. E-mail: bill.barrow{at}okstate.edu.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4801-4803, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4801-4803.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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