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Antimicrobial Agents and Chemotherapy, November 2005, p. 4804-4806, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4804-4806.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Impact of Mass Distribution of Azithromycin on the Antibiotic Susceptibilities of Ocular Chlamydia trachomatis

Anthony W. Solomon,1,2,3* Zeena Mohammed,4 Patrick A. Massae,2 John F. Shao,3 Allen Foster,1 David C. W. Mabey,1 and Rosanna W. Peeling4,5

Clinical Research Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom,1 Huruma Hospital, Mkuu, Rombo, Tanzania,2 Kilimanjaro Christian Medical Centre, Tumaini University, Moshi, Tanzania,3 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada,4 UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland5

Received 20 June 2005/ Returned for modification 12 July 2005/ Accepted 19 August 2005

In a community of Tanzania where trachoma is endemic, we cultured conjunctival swabs from all residents who had active trachoma and were PCR positive for ocular Chlamydia trachomatis, both before (43 isolates) and 2 months after (9 isolates) mass antibiotic treatment. No clinically or programmatically significant increase in azithromycin or tetracycline resistance was observed.

* Corresponding author. Mailing address: Clinical Research Unit, London School of Hygiene & Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. Phone: 44 (0)20 7958 8336. Fax: 44 (0)20 7958 8338. E-mail: anthony.solomon{at}lshtm.ac.uk.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4804-4806, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4804-4806.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Feasey, N., Wansbrough-Jones, M., Mabey, D. C. W., Solomon, A. W. (2009). Neglected tropical diseases. Br Med Bull 0: ldp046v1-ldp046 [Abstract] [Full Text]  
  • Porco, T. C., Gebre, T., Ayele, B., House, J., Keenan, J., Zhou, Z., Hong, K. C., Stoller, N., Ray, K. J., Emerson, P., Gaynor, B. D., Lietman, T. M. (2009). Effect of Mass Distribution of Azithromycin for Trachoma Control on Overall Mortality in Ethiopian Children: A Randomized Trial. JAMA 302: 962-968 [Abstract] [Full Text]  
  • Mabey, D., Solomon, A. W. (2008). Mass Antibiotic Administration for Eradication of Ocular Chlamydia trachomatis. JAMA 299: 819-821 [Full Text]  


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