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Antimicrobial Agents and Chemotherapy, December 2005, p. 4989-4992, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.4989-4992.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Comparison of the Fungicidal Activities of Caspofungin and Amphotericin B against Candida glabrata

Istituto di Malattie Infettive e Medicina Pubblica,¹ Centro di Gestione Presidenza Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy²

Received 30 July 2005/ Returned for modification 12 September 2005/ Accepted 27 September 2005

We investigated the fungicidal activity of caspofungin (CAS) and amphotericin B (AMB) against 16 clinical isolates of Candida glabrata. The minimum fungicidal concentrations (MFCs) of CAS were similar to those of AMB, ranging from 2.0 to >8.0 µg/ml. Time-kill assays performed on selected isolates showed that AMB was fungicidal at concentrations four times the MIC while CAS was not. A neutropenic-mouse model of disseminated infection was utilized to determine the residual fungal kidney burden. While doses as low as 0.3 and 1 mg/kg of body weight/day of CAS and AMB, respectively, were effective at reducing the counts with respect to controls, organ sterilization was reached when both drugs were administered at 5 mg/kg/day. Our study reveals that, similar to AMB, CAS has the potential for a fungicidal effect in vivo against this difficult-to-treat fungal pathogen.

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