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Antimicrobial Agents and Chemotherapy, December 2005, p. 5119-5122, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5119-5122.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Moxifloxacin and Azithromycin but not Amoxicillin Protect Human Respiratory Epithelial Cells against Streptococcus pneumoniae In Vitro when Administered up to 6 Hours after Challenge

Martina Ulrich,1 Cordula Albers,1 Jan-Georg Möller,2 Axel Dalhoff,3 Gisela Korfmann,4 Frank Künkele,4 and Gerd Döring1*

Institute of Medical Microbiology and Hygiene, Universitätsklinikum Tübingen, Tübingen,1 Bayer HealthCare, Wuppertal,2 Institute of Medical Microbiology and Virology, Universitätsklinikum Schleswig Holstein,3 Bayer Vital GmbH, Leverkusen, Germany4

Received 11 May 2005/ Returned for modification 7 July 2005/ Accepted 2 September 2005

We determined the protective effect of moxifloxacin, azithromycin, and amoxicillin against Streptococcus pneumoniae infection of respiratory cells. Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, Universitätsklinikum Tübingen, Wilhelmstrasse 31, D-72074 Tübingen, Germany. Phone: (49) 7071-298-2069. Fax: (49) 7071-29-3011. E-mail: gerd.doering{at}med.uni-tuebingen.de.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5119-5122, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5119-5122.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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