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Antimicrobial Agents and Chemotherapy, December 2005, p. 5127-5128, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5127-5128.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pitfalls in Estimating Piperaquine Elimination

Joel Tarning,1 Niklas Lindegårdh,2 Anna Annerberg,2 Thida Singtoroj,2 Nicholas P. J. Day,2 Michael Ashton,1 and Nicholas J. White2*

Department of Pharmacology, Göteborg University, Sahlgrenska Academy, Göteborg, Sweden,1 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand2

Received 12 September 2005/ Accepted 12 September 2005

By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.

* Corresponding author. Mailing address: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: (66)-2-354-9172. Fax: (66)-2-354-9169. E-mail: nickw{at}tropmedres.ac.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5127-5128, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5127-5128.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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