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Antimicrobial Agents and Chemotherapy, December 2005, p. 5133-5135, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5133-5135.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efficacy of Caspofungin against Aspergillus terreus

Francesco Barchiesi,1* Elisabetta Spreghini,1 Alfredo Santinelli,2 Annette W. Fothergill,6 Stefania Fallani,5 Esther Manso,4 Eleonora Pisa,2 Daniele Giannini,3 Andrea Novelli,5 Maria I. Cassetta,5 Teresita Mazzei,5 Michael G. Rinaldi,6,7 and Giorgio Scalise1

Istituto di Malattie Infettive e Medicina Pubblica,1 Istituto di Anatomia Patologica,2 Centro Gestione Presidenza Medicina e Chirurgia, Università Politecnica delle Marche,3 Laboratorio di Microbiologia Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy,4 Istituto di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy,5 Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas,6 Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas7

Received 23 July 2005/ Returned for modification 1 September 2005/ Accepted 3 October 2005

We investigated the in vitro and in vivo activities of caspofungin against Aspergillus terreus. The drug increased survival and reduced tissue fungal burden in neutropenic mice. Therefore, our data support the role of caspofungin in treating systemic infections due to this emerging pathogen.

* Corresponding author. Mailing address: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-Lancisi-Salesi, Via Conca, Torrette, Ancona 60020, Italy. Phone: 39.0715963467. Fax: 39.0715963468. E-mail: l.infettive{at}ao-umbertoprimo.marche.it.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5133-5135, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5133-5135.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Antachopoulos, C., Meletiadis, J., Sein, T., Roilides, E., Walsh, T. J. (2007). Concentration-Dependent Effects of Caspofungin on the Metabolic Activity of Aspergillus Species. Antimicrob. Agents Chemother. 51: 881-887 [Abstract] [Full Text]  
  • Bowman, J. C., Abruzzo, G. K., Flattery, A. M., Gill, C. J., Hickey, E. J., Hsu, M. J., Nielsen Kahn, J., Liberator, P. A., Misura, A. S., Pelak, B. A., Wang, T. C., Douglas, C. M. (2006). Efficacy of Caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. Antimicrob. Agents Chemother. 50: 4202-4205 [Abstract] [Full Text]  


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