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Antimicrobial Agents and Chemotherapy, December 2005, p. 5146-5148, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5146-5148.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Attenuation of the Activity of Caspofungin at High Concentrations against Candida albicans: Possible Role of Cell Wall Integrity and Calcineurin Pathways

The University of Houston College of Pharmacy,¹ The University of Texas M. D. Anderson Cancer Center, Houston, Texas,² The University of Texas at Austin College of Pharmacy, Austin, Texas,³ The University of Texas Health Science Center at San Antonio, San Antonio, Texas⁴

Received 25 July 2005/ Returned for modification 6 September 2005/ Accepted 10 September 2005

Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 µg/ml. This phenomenon was markedly attenuated in a mkc1/mkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways.

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