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Antimicrobial Agents and Chemotherapy, December 2005, p. 5149-5152, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5149-5152.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Variants of the Klebsiella pneumoniae OKP Chromosomal Beta-Lactamase Are Divided into Two Main Groups, OKP-A and OKP-B

Cindy Fevre, Virginie Passet, François-Xavier Weill, Patrick A. D. Grimont, and Sylvain Brisse*

Unité Biodiversité des Bactéries Pathogènes Emergentes (U389 INSERM), Institut Pasteur, 25-28 rue du Dr. Roux, 75 724 Paris Cedex 15, France

Received 29 July 2005/ Returned for modification 16 September 2005/ Accepted 22 September 2005

Two blaOKP subgroups were found, diverging by 4.2%. Subgroups blaOKP-A (10 enzyme variants, pIs from 7.1 to 8.3) and blaOKP-B (11 variants, pI 7.1) showed similar antibiotic susceptibilities. Sequencing of rpoB, gyrA, and mdh demonstrated a concordant subdivision of Klebsiella pneumoniae phylogenetic group KpII into two subgroups, KpII-A and KpII-B.

* Corresponding author. Mailing address: Unité Biodiversité des Bactéries Pathogènes Emergentes (U389 INSERM), Institut Pasteur, 25-28 rue du Dr. Roux, 75 724 Paris Cedex 15, France. Phone: 33 (0) 1 40 61 33 57. Fax: 33 (0) 1 45 68 88 37. E-mail: sbrisse{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5149-5152, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5149-5152.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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